红霉素

性状描述: 白色或类白色结晶或粉末。无气味。味苦。有吸湿性。易溶于醇类、丙酮、氯仿、乙腈和乙酸乙酯,溶于乙醚、二氯乙烷和乙酸戊酯,水中溶解度约2mG/ml。在水中析出的含水结晶熔点 135～140℃。比旋光度[α]25D-78°(c=1.99,乙醇中)。最大吸收波长(pH 6.3)280nm(ε50)。PKA18.8。

质量标准: 品级Grade                               USP级  
                                        (USP)
identity                                pass
比旋度Specific rotation [a]20/D         -71°～ -78° (c=2, 乙醇)
crystallinity                           pass
water content by karl fischer           ≤ 10.0%
residue on ignition                     ≤ 0.2%
limit of thiocyanate                    ≤ 0.3%
limit of related substances
erythromycin a enol ether              ≤ 3.0%  
erythromycin b                         ≤ 12.0%  
erythromycin c
residual solvents                       ≤5.0% meets the requirements
assay (total of erythromycin a, b & c)  85.0 to 100.5% (anhydrousbasis)



项目                                    Eur.Pharm.
外观Appearance                          白色至微黄色粉末或无色或微黄色结晶
红外光谱鉴定Infrared spectrometry       和对照品匹配
熔点Melting point                       38°C - 42°C
纯度Purity（以干基计）                  93.0 - 102.0% (HPLC) (红霉素A, B 和 C的总和)
红霉素erythromycin B                    
<5.0 % (HPLC) >红霉素erythromycin C                    
<5.0 % (HPLC) >水分Water                              
<6.5 % (K.F.) >硫酸盐灰分Sulfated ash                  
<0.2 % (1.0 g) >比旋度Specific rotation [a]20/D         -71°～ -78° (c=2, 乙醇)
鉴别试验Identification per Eur. Pharm.
A:                                     passes test
B:                                     passes test
C:                                     red coloration
D:                                     yellow coloration
硫氰酸Thiocyanate(SCN)                  
<0.3 % >相关物质related substances (HPLC):      通过测试(per Eur. Pharm.)


项目                                    生化试剂级
                                      （BC,用于细胞培养）
外观Appearance                          白色至微黄色粉末
红外光谱鉴定Infrared spectrometry       和对照品匹配
熔点Melting point                       38°C - 42°C
纯度Purity                              ≥98.0% (TLC)
效价POTENCY                             ≥ 850 UG ERYTHROMYCIN/MG  
水分Water                              
<6.5 % (K.F.) >硫酸盐灰分Sulfated ash                  
<0.2 % >比旋度Specific rotation [a]20/D         -71°～ -78°(c=2, 乙醇)
30分钟后., 以干基计


项目                                    98%
纯度Purity(Nonaqueous Titration)        ≥98.0 %(anhydrous)
比旋光度Specific rotation [a]20/D       -71.0 to -78.0 °(C=2, EtOH)(anhydrous)
水分Water                               ≤10.0 %

储存条件: 充氩密封干燥保存。

用途: 生化研究。制菌物质。能与核蛋白体结合抑制细菌蛋白的合成。